NABP NABP Certifications NAPLEX Questions & Answers

• Question 91:

  If a patient is getting NS IVF at 120mls/hr, how much Sodium Chloride in grams is this patient getting in 24 hours? NS is 0.9% sodium chloride.

  A. 25.92gm

  B. 25.92kg

  C. 25.92mg

  D. 90mg

  E. 90gm

  Correct Answer: A

• Question 92:

  Which of the following class of antidiabetic medication may cause fluid retention?

  A. Bile acid sequestrant

  B. GLP-1 agonist

  C. Thiazolidinediones

  D. SGLT2 Inhibitor

  E. Alpha-glucosidase inhibitor

  Correct Answer: C

  Thiazolidinediones may cause fluid retention through proposed mechanism of increasing reabsorption in the collecting duct of the kidney and increasing vascular permeability in adipose tissue. Bile acid sequestrants work in the intestine to bind bile acids which doesn't affect fluid retention. GLP-1 receptor agonists work to activate these receptors to secrete insulin from beta pancreatic cells/decrease glucagon secretion/ increase satiety and doesn't affect fluid retention. SGLT2 inhibitors actually cause increase of fluid elimination through the kidneys. Alpha-glucosidase inhibitors work in the gut to decrease carb absorption/digestion and have no affect on fluid retention.

• Question 93:

  Which of the following antidiabetic medication works by decreasing glucose reabsorption?

  A. Miglitol

  B. Linagliptin

  C. Pioglitazone

  D. Exenatide

  E. Empagliflozin

  Correct Answer: E

  Empagliflozin is a SGLT2 inhibitor to decrease glucose reabsorption in the kidney. Linagliptin is a DPP-4 inhibitor that works on incretins/increase insulin secretion/decrease glucagon secretion. Pioglitazone is a TZD that increases insulin sensitivity. Exenatide is a GLP-1 agonist which increase insulin secretion/ decrease glucagon secretion/increase satiety.

• Question 94:

  Which of the following is dichotomous variable?

  A. Sex

  B. Pain yes/ Pain no

  C. alive / dead

  D. Grade of Breast Cancer

  E. NYHA I-IV

  Correct Answer: C

  Dichotomous data is considered categorical data that only has two categories, or two answer choices. All 3 answer choices have only 2 categories: sex has male or female, pain is yes or no, and alive or dead is only two options also.

  Reference: http://www.bmj.com/about-bmj/resources-readers/publications/statistics-square-one

• Question 95:

  Which of the following should be monitored when a patient is on SGLT2 inhibitor?

  A. Hydration status

  B. Blood pressure

  C. Blood glucose

  D. Renal function

  E. All of the above

  Correct Answer: E

  Because SGLT2 inhibitors work by preventing reabsorption of glucose in the kidneys, this increases frequency of urination. All of the options are monitoring requirements since the hydration status, blood pressure, blood glucose, and renal function may all be changed from increased urination (from the mechanism of the drug).

• Question 96:

  Which of the following medication should be avoided in patients with heart failure?

  A. Cilostazol

  B. Pioglitazone

  C. Naproxen

  D. Celebrex

  E. All of the above

  Correct Answer: E

  Patients with heart failure should avoid taking NSAIDs (which includes naproxen), COX-2 inhibitors, nondihydropyridine calcium channel blockers (for reduced EF), thiazolidinediones (which includes pioglitazone), cilostazol, and dronedarone (for severe or recently decompensated heart failure).

• Question 97:

  Which of the following medication can lower seizures threshold?

  A. Bupropion

  B. Tramadol

  C. Clozapine

  D. Thiothixene

  E. All of the above can lower seizure threshold

  Correct Answer: E

  Seizure threshold can be lowered by bupropion, chlorpromazine, clozapine, maprotiline, olanzapine, thioridazine, thiothixene, and tramadol.

• Question 98:

  A Physician orders amiodarone 1 mg/min for six hours, then 0.5 mg/min thereafter. The patient's weight is 156 lbs. The concentration of the IV bag comes as 1.8 mg per ml. Calculate the infusion rate in mL/hr.

  A. 33.33mls/hr then /16.67mls/hr

  B. 60mls/hr then 30mls/hr

  C. 30mls/hr then 15mls/hr

  D. 16.67mls/hr then 8.3mls/hr

  E. 8.3mls/hr then 4.15mls/hr

  Correct Answer: A

• Question 99:

  Which of the following medication may increase LDL?

  A. Lisinopril

  B. Hydrochlorothiazide

  C. Diltiazem

  D. Metoprolol

  E. Amlodipine

  Correct Answer: B

  LDL can be elevated by diuretics, cyclosporine, glucocorticoids, and amiodarone.

• Question 100:

  In Normal distribution, what percentage of the sample is found within 2 standard deviation of the mean?

  A. 68%

  B. 95%

  C. 99%

  D. 100%

  E. 72%

  Correct Answer: B

  In a normal distribution sample, within 1 standard deviation 68% of the sample falls within 1 standard deviation, 95% within 2 standard deviations, and 99.7% within 3 standard deviations of the mean.

  Reference: http://www.bmj.com/about-bmj/resources-readers/publications/statistics-square-one