NABP NABP Certifications FPGEE Questions & Answers

• Question 121:

  Diazepam Injection U.S.P

  Diazepam 5 mg/ml

  Ethanol 10%

  Propylene glycol 40%

  Benzyl alcohol 1.5%

  Water for Injection qs 100%

  In the formulation given above, the following ingredient(s) function(s) as a coso|vent(s):

  I ethanol

  II propylene glycol

  III benzyl alcohol

  A. I only

  B. III only

  C. I and II only

  D. II and III only

  E. I, II and III

  Correct Answer: C

• Question 122:

  Both isoxazole and oxazole rings are found as substituents in some bacteriostatic sulfanilamides. They are present in these structures specifically because of their:

  A. Sizes and shapes

  B. Tautomeric activities

  C. Enzymatic activities

  D. Electron-donating effects

  E. Electron-withdrawing effects

  Correct Answer: E

• Question 123:

  The Michaelis-Menten equation will appear first order:

  A. when the substrate concentration is much smaller than Km.

  B. when Km is much smaller than the substrate concentration.

  C. when Vmax is much smaller than Km.

  D. when Vmax is much larger than Km.

  E. when Km approaches Vmax.

  Correct Answer: A

• Question 124:

  With respect to bioalence, the parameter "Cmax" is:

  A. Affected by the extent of absorption only.

  B. Affected by the rate of absorption only.

  C. Affected by neither rate nor extent of absorption.

  D. Affected by both rate and extent of absorption.

  E. The only significant parameter.

  Correct Answer: D

• Question 125:

  Which of the hydroxyls in the compound above is a tertiary alcohol?

  A. Hydroxyl 1

  B. Hydroxyl 2

  C. Hydroxyl 3

  D. Hydroxyl 4

  E. Hydroxyls 1 and 2

  Correct Answer: B

• Question 126:

  The above structures are related to one another as:

  A. bioisosteres

  B. enantiomers

  C. homologs

  D. rotamers

  E. positional (structural) isomers

  Correct Answer: C

• Question 127:

  Five subjects given a single intravenous dose of a drug have the following elimination half-lives: 3, 9, 6, 5 and 4 h (hours). The mean half-life is:

  A. 4.0 h.

  B. 5.0 h.

  C. 5.4 h.

  D. 5.8 h.

  E. 6.0 h.

  Correct Answer: C

• Question 128:

  Reasons for using coatings on tablets include all of the following, EXCEPT:

  A. to mask the taste of the drug

  B. to mask the odor of the drug

  C. to improve the appearance of the tablet

  D. to increase the drug's release rate

  E. to protect the drug from stomach acid

  Correct Answer: D

• Question 129:

  Which of the following factors would be important in determining the concentration of drug that would be reached in the cerebrospinal fluid for treatment of meningitis?

  I Oil/water partition coefficient II Binding to plasma protein III pKa of the drug

  A. I only

  B. III only

  C. I and II only

  D. II and III only

  E. I, II and III

  Correct Answer: E

• Question 130:

  Which of the following terms indicates a loss of moisture?

  A. Deliquescence

  B. Efflorescence

  C. Hygroscopicity

  D. Polymorphism

  E. Condensation

  Correct Answer: B