Given that the VD = 230 L/70Kg and Cl = 60 L/hr/70 Kg for morphine, approximately how much of a 10 mg IV dose remains after 8 hr, given to a normal 70 Kg patient?
A. 5 mg
B. 2.5 mg
C. 1.25 mg
D. 625 mg
Given F = .24, what is the overall hepatic clearance of morphine if the above patient has portal hypertension such that their hepatic blood flow is reduced by .? Assume the clearance value given in the previous question is entirely hepatic clearance.
A. 30 L/hr/70 Kg
B. 60 L/hr/70 Kg
C. 120 L/hr/70 Kg
D. 250 L/hr/70 Kg
Which of the following enzymes could directly act on codeine?
A. Glucuronyl transferase
B. Sulfotransferase
C. Glutathione transferase
D. A and B
E. All of the above
Which Cytochrome P450 isozyme does not participate appreciably in drug metabolism?
A. CYP1A2
B. CYP2C9
C. CYP3A4
D. CYP51
E. All are drug metabolizing isoforms
Which of the following Cytochrome P450 isozymes is responsible for the bulk of phase I metabolism?
A. CYP1A2
B. CYP2C9
C. CYP2D6
D. CYP3A4
E. CYP51
In a zero order elimination process, which of the following is true?
A. The removal of drug is independent of drug concentration
B. CI = Elimination rate/Cp
C. t1/2 = .7VD/CI
D. All are true
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