NABP NABP Certifications FPGEE Questions & Answers

• Question 131:

  Physicochemical factors affecting the rate and extent of percutaneous drug absorption include:

  I the partition coefficient of the drug molecule II the presence of surfactants in the formulation III the type of ointment base

  A. I only

  B. III only

  C. I and II only

  D. II and III only

  E. I, II and III

  Correct Answer: E

• Question 132:

  In cardiovascular physiology, LaP|ace's law relates the tension achieved in a blood vessel wall to:

  I the length of the vessel II the radius of vessel III the intraluminal pressure

  A. I only

  B. III only

  C. I and II only

  D. II and III only

  E. I, II and III

  Correct Answer: D

• Question 133:

  Concentration of a drug in breast milk exceeds that in plasma, if the drug:

  A. Is basic.

  B. Is protein bound.

  C. Is acidic but not protein bound.

  D. Has a small volume of distribution.

  E. Has a large volume of distribution.

  Correct Answer: A

• Question 134:

  Mercapturic acid derivatives in phase II metabolism can result from reactions of:

  A. glutathione conjugates.

  B. glucuronide conjugates.

  C. glycine conjugates.

  D. glutamate conjugates.

  E. sulfate conjugates.

  Correct Answer: A

• Question 135:

  Tetrodotoxin is a selective inhibitor of the:

  A. calcium ion channel

  B. sodium ion channel

  C. potassium ion channel

  D. chloride ion channel

  E. nicotinic ion channel

  Correct Answer: B

• Question 136:

  Atropine is the primary example of an important class of muscarinic antagonists which are esters of tropic acid and which contain:

  A. aniline and piperidine rings.

  B. aniline and piperazine rings.

  C. aniline and pyrrolidine rings.

  D. pyrrolidine and piperazine rings.

  E. pyrrolidine and piperidine rings.

  Correct Answer: E

• Question 137:

  Common etiologic agents of community-acquired pneumonia include:

  I Escherichia coli II Haemophilus influenzae III Mycoplasma pneumoniae

  A. I only

  B. III only

  C. I and II only

  D. II and III only

  E. I, II and III

  Correct Answer: D

• Question 138:

  Gamma aminobutyric acid (GAB) is:

  I the major inhibitory neurotransmitter in the brain Il found primarily in interneurons III synthesized from glycine

  A. I only

  B. III only

  C. I and II only

  D. II and III only

  E. I, II and III

  Correct Answer: C

• Question 139:

  All of the following statements are true regarding chronic inflammation, EXCEPT:

  A. It may develop as a granulomatous inflammation.

  B. It may be caused by persistent infections such as tuberculosis.

  C. It may occur with autoimmune diseases such as rheumatoid arthritis.

  D. large numbers of macrophages are found in the infiltrate.

  E. Lymphocytes and eosinophils are rarely involved in its development.

  F. Pharmaceutical Sciences

  Correct Answer: E

• Question 140:

  If the pKa of phenobarbital is 7.4, what approximate fraction of the drug would be ionized at pH 8.4?

  A. 10%

  B. 30%

  C. 50%

  D. 90%

  E. 100%

  Correct Answer: D