Autoimmune disorders include which of the following?
I Graves' disease II Systemic Lupus Erythematosus III Osteoarthritis
A. I only
B. III only
C. I and II only
D. II and III only
E. I, II and III
Acute hemorrhagic gastritis is commonly seen with:
A. chronic alcoholism
B. H. pylori bacterial infections
C. carcinoma of the stomach
D. carcinoma of the colon
E. Travellers' diarrhea
True statements regarding the use of monoclonal antibodies include which of the following?
I. Flu-like symptoms commonly occur at the start of therapy.
II. T cells are blocked from initiating the rejection process.
III.
Orthoclone is a human immunoglobulin product.
A.
I only
B.
III only
C.
I and II only
D.
II and III only
E.
I, II and III
Select the drug whose major metabolites have therapeutically significant pharmacological activity:
A. oxazepam
B. nitrazepam
C. diazepam
D. triazolam
E. clonazepam
The major pathway for the biotransformation of the following compound is by hydrolysis. Identify the site which would be most susceptible to hydrolysis.
A. A
B. B
C. C
D. D
E. E
Biceps muscles are part of:
I the arm II the thigh III the rib cage
A. I only
B. III only
C. I and II only
D. II and III only
E. I, II and III
The mechanism of antipsychotic effect of phenothiazines is thought to be due to:
A. improvement of cholinergic transmission
B. blockade of catecholamine re-uptake
C. blockade of dopamine receptors
D. blockade of enkephalinergic neurons
E. prolactin release
Mechanisms of drug interactions with acetylsalicylic acid (AS
A. include:
B. induction of microsomal enzymes
C. inhibition of microsomal enzymes
D. inhibition of liposomal enzymes
E. displacement of other drugs bound to serum albumin
F. enhanced platelet aggregation
All of the following drugs will increase the heart rate directly or by refilex when injected intravenously into a young healthy adult, EXCEPT:
A. isoproterenol
B. histamine
C. phentolamine
D. phenylephrine
E. atropine
Which of the following diuretics is used to block the Na?H+ exchange system of the renal tubule?
A. Furosemide
B. Hydrochlorothiazide
C. Spironolactone
D. Acetazolamide
E. Amiloride
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