ASCP ASCP-MLT Online Practice Questions and Exam Preparation

ASCP ASCP-MLT Online Questions & Answers

• Question 31:

  Though automated extraction machines have many benefits over manual methods the costs are high and generally require a high throughput of samples in order to justify the costs.

  Automated extraction has many benefits over the traditional manual methods. The most important benefit is that the nucleic acid isolated is constantly consistent. There is a reduced amount of manipulation with dramatically decreases the chance of cross contamination. Also, automated extraction machines are considered moderate complexity and can be performed by a wider variety of laboratory professionals. All of the following are considered benefits of automated isolation and extraction equipment EXCEPT:

  A. Automated isolation equipment is cheaper and more practical
  B. Automated isolation equipment requires less manipulation
  C. Automated isolation equipment is considered moderate complexity
  D. Automated isolation equipment provides consistent results
  A. Automated isolation equipment is cheaper and more practical

• Question 32:

  Oxalate, EDTA, and citrate are anticoagulants that inhibit clot formation.

  Which of the following blood additives is most useful for serum collection:

  A. Polymer barrier
  B. Oxalate
  C. EDTA
  D. Citrate
  A. Polymer barrier

• Question 33:

  A hapten is an incomplete antigen.

  All of the following cellular antigens are important to an immunohematologist except:

  A. Blood group antigens
  B. Histocompatibility antigens
  C. Haptens
  D. Autoantigens
  C. Haptens

• Question 34:

  A test with high specificity accurately detects the absence of disease. The more specific a test is, the fewer false-positive results will occur. A test with high sensitivity accurately identifies the presence of disease. The more sensitive a test, the fewer false-negative results it produces. In the case stated in this question, the immunoassay has high specificity, so it has few false-positives and will accurately detect those individuals who do not have the disease or condition that is being tested for. However, the test has low sensitivity, so it may not identify all individuals who actually have the disease; it may produce many false-negative results.

  The accuracy of an immunoassay is its ability to discriminate between results that are true positives and results that are true negatives. Two parameters of test accuracy are specificity and sensitivity. Which of these statements apply to an immunoassay with high specificity, but low sensitivity?

  A. Accurately identifies the presence of disease
  B. Accurately identifies the absence of disease
  C. Has few false-positives
  D. Has few false-negatives
  B. Accurately identifies the absence of disease
  C. Has few false-positives

• Question 35:

  Glycoprotein IIb/IIIa is integral in the process of platelet aggregation as well as clot retraction.

  A defective clot retraction might be caused by which one of these?

  A. Lack of or defect of platelet receptor glycoprotein Ib
  B. Lack of or defect of platelet receptor Ilb/IIIa
  C. Insufficient storage of ADP in platelet granules
  D. Absence or defect of von Willebrand's factor
  B. Lack of or defect of platelet receptor Ilb/IIIa

• Question 36:

  This antibody is found in the serum of Le(a-b-) secretors.

  Which one of these Lewis blood group system phenotypes usually produces anti-Lea?

  A. Le(a+b+)
  B. Le(a+b-)
  C. Le(a--b+)
  D. Le(a--b-)
  D. Le(a--b-)

• Question 37:

  This patient is most likely suffering from an immediate-acting coagulation inhibitor; most commonly, lupus anticoagulant. Notice that the addition of normal pooled plasma does not correct upon initial or incubated mix, which means that the

  inhibitor is not time or temperature-dependent.

  Factor VIII is not the correct answer as a factor deficiency would have corrected upon the addition of normal pooled plasma. Factor VII is not the correct answer, as the aPTT assay does not account for factor VII activity or concentration.

  The laboratorian completed the mixing study ordered for John Doe. The results are as follows:

  Initial aPTT result: 167 seconds

  Initial 1:1 Mix with Normal Pooled Plasma: 158 seconds

  Incubated 1:1 Mix with Normal Pooled Plasma: 150 seconds

  Which of the choices below would most likely explain the results for this patient?

  A. Factor VIII deficiency
  B. Immediate-acting coagulation inhibitor
  C. Time/temperature-dependent coagulation inhibitor
  D. Factor VII deficiency
  B. Immediate-acting coagulation inhibitor

• Question 38:

  Troponin is potentially more specific for myocardial damage than CK-MB and stays elevated longer. It may eventually replace CK-MB as the standard marker of myocardial damage. In addition, troponin T has been known to be elevated in the setting of even mild degrees of renal failure. Troponin and CK-MB both tend to rise approximately 3 hours after a MI (hence why the correct answer is "A", since it is false); however, troponins can stay elevated up to 2 weeks as CK-MB tends to return to baseline around 36 hours.

  Chemistry

  Which of the following statements is FALSE regarding troponin?

  A. It rises much sooner after an MI than CK-MB
  B. It stays positive much longer than CK-MB
  C. It is potentially more specific than CK-MB
  D. Troponin T is often elevated in renal failure patients
  A. It rises much sooner after an MI than CK-MB

• Question 39:

  The role of the point-of-care testing (POCT) compared with in-laboratory testing is the

  A. Specific microscopic tests (wet mounts) performed by a physician for his or her own patients
  B. Process of performin laboratory testing at the bedside of the patient and a means of decentralizing some of the laboratory testing
  C. Means by which quality control between laboratories is maintained
  D. Continuation of the process of evaluating and monitoring all aspects of the laboratory to ensure accuracy of test results
  B. Process of performin laboratory testing at the bedside of the patient and a means of decentralizing some of the laboratory testing

• Question 40:

  The parents will each give one of their ABO genes, so the possibilities are as follows:

  AB, AO, AB, AO = 50% chance of A blood type, 50% chance of AB blood type

  Blood Bank

  If parents have the blood group genotypes AA and BO, what is the possibility of having a child with a blood type of A?

  A. 25%
  B. 50%
  C. 75%
  D. 100%
  E. none of them
  B. 50%