A 73-year-old man is brought to his primary care physician by his wife who is concerned about her husband's progressive memory problems over the past year. She notes that he originally began forgetting to do his normal household chores,
and then started routinely misplacing things around the house; he has also forgotten to close or lock doors or turn off the oven and has left the car running in the garage. He is having trouble remembering the driving routes to familiar places and names of longtime friends and acquaintances. The patient's neurological examination reveals disorientation to place and time, inability to recall three objects, and difficulty following a threestage command.
Based on this information, which of the following best explains the pathogenesis of his condition?
Q12
Single choice