Q17
Single choice
A patient with HIV infection and a CD4+ T-cell count below 50 cells/ develops a progressive neurological illness characterized by confusion, motor deficits, and seizures. Brain MRI reveals multiple white matter lesions without mass effect. PCR of the CSF is positive for JC virus. Thepathogenesis of this condition,
progressive multifocal leukoencephalopathy (PML), involves: